Associate Director, Biomarker Development
Brisbane, CA
Full Time
Experienced
Gate Bioscience is a venture-backed, preclinical biotech company creating a new class of medicines called Molecular Gates. Our therapeutics are small molecules that aim to cure diseases by selectively eliminating harmful extracellular proteins at their origin: inside the cell. Every extracellular protein—of which there are more than 4,000—must pass through a single channel in the cell before it can be secreted into the body. Molecular Gates bind to this channel, setting up a “gate” that recognizes and blocks a specific, disease-causing protein from exiting. With nowhere to go, the protein is degraded instead of being secreted. By eliminating the harmful protein at the source, Gate aims to eliminate the disease for patients. Founded in 2021, Gate is backed by Versant Ventures, a16z Bio + Health, ARCH Venture Partners, and GV. Learn more at www.gatebio.com.
We are seeking a dynamic, tenacious and meticulous Biomarker Scientist to join our growing Translational Science team. This role will play a vital role in developing the translational biomarker strategy and driving Gate’s small molecule programs to IND and into First-In-Human (FIH) studies. The successful candidate will have deep expertise in small molecule drug discovery from early pre-clinical to Ph1 studies and provide scientific leadership for biomarkers. This role reports to the Senior Director of Translational Science. This role is on-site.
In this role you will:
Education and Experience:
Compensation:
Below is the expected salary range for this position. Individual compensation is based on various factors, including level, experience, education, skill set, and geographic location. This range is for our San Francisco Bay Area, location and may be adjusted to the labor market in other geographic areas.
Target Salary Range: $190,000 - $215,000
In addition to salary, Gate Bioscience offers equity in the company, a robust benefits package, 401(k) program with employer match, and the opportunity to be a part of ground-breaking research.
We are seeking a dynamic, tenacious and meticulous Biomarker Scientist to join our growing Translational Science team. This role will play a vital role in developing the translational biomarker strategy and driving Gate’s small molecule programs to IND and into First-In-Human (FIH) studies. The successful candidate will have deep expertise in small molecule drug discovery from early pre-clinical to Ph1 studies and provide scientific leadership for biomarkers. This role reports to the Senior Director of Translational Science. This role is on-site.
In this role you will:
- Lead the development and execution of translational biomarker strategy for Gate’s three lead programs as they move from discovery to early clinical development
- Direct the development, validation and outsourcing of clinically applicable biomarker assays and design, implement and oversee biomarker testing and data analysis - with a key focus on understanding PK/PD in rodent, higher species and in FIH studies
- Serve as a Translational/Biomarker Lead for a program and work with cross-functional program team as it transitions into development
- Establish and cultivate relationships with high quality external CRO collaborators, as well as key opinion leaders and academic sites
- Coordinate shipment, analysis and storage of samples from PK/PD studies from multiple stakeholders
- Contribute to the preparation of IND applications and other regulatory documents, as appropriate
- Present findings to internal teams and at scientific conferences, as well as contribute to scientific publications
Education and Experience:
- PhD/MD in Biology or related fields, with 12+ years of post-graduate experience in industry
- Experience with transitioning small molecules from preclinical experiments to Ph1 studies, particularly in the design and execution of PK/PD studies in rodents, higher species and humans
- Proven track record of having developed and implemented novel clinical biomarkers
- Strong experimentalist, with a desire to be hands on and to troubleshoot complex assays on the bench with grit and determination
- Hands on experience with multiple techniques for biomarker analysis (flow cytometry, WB, ELISA, MSD, HTRF, LC-MS, proteomics), as well as an early adopter of novel technologies
- Engineering mindset with excellent record keeping & attention to detail
- Experience as a Biology/Translational/Biomarker lead on cross-functional project teams
- Experience with management of direct report(s)
- Desire to work across multiple therapeutic areas with diverse sample types
- Prior experience working with small molecules and in smaller companies is highly preferred
Compensation:
Below is the expected salary range for this position. Individual compensation is based on various factors, including level, experience, education, skill set, and geographic location. This range is for our San Francisco Bay Area, location and may be adjusted to the labor market in other geographic areas.
Target Salary Range: $190,000 - $215,000
In addition to salary, Gate Bioscience offers equity in the company, a robust benefits package, 401(k) program with employer match, and the opportunity to be a part of ground-breaking research.
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